Table 5 DNA-binding TF gene classification counts
From: TFCat: the curated catalog of mouse and human transcription factors
Protein group | Protein group description | Protein family | Protein family description | Gene count | Predicted occurrences |
|---|---|---|---|---|---|
1.1 | Helix-turn-helix group | 2 | Homeodomain family | 131 | 160 |
1.1 | Helix-turn-helix group | 100 | Myb domain family | 7 | 16 |
1.1 | Helix-turn-helix group | 109 | Arid domain family | 5 | 5 |
1.1 | Helix-turn-helix group | 999 | No family level classification | 2 | 2 |
1.2 | Winged helix-turn-helix | 13 | Interferon regulatory factor | 7 | 7 |
1.2 | Winged helix-turn-helix | 15 | Transcription factor family | 10 | 11 |
1.2 | Winged helix-turn-helix | 16 | Ets domain family | 23 | 23 |
1.2 | Winged helix-turn-helix | 101 | GTF2I domain family | 2 | 12 |
1.2 | Winged helix-turn-helix | 102 | Forkhead domain family | 26 | 26 |
1.2 | Winged helix-turn-helix | 103 | RFX domain family | 4 | 4 |
1.2 | Winged helix-turn-helix | 111 | Slide domain family | 1 | 1 |
2.1 | Zinc-coordinating group | 17 | Beta-beta-alpha-zinc finger family | 79 | 450 |
2.1 | Zinc-coordinating group | 18 | Hormone-nuclear receptor family | 43 | 43 |
2.1 | Zinc-coordinating group | 19 | Loop-sheet-helix family | 1 | 1 |
2.1 | Zinc-coordinating group | 104 | GATA domain family | 7 | 12 |
2.1 | Zinc-coordinating group | 105 | Glial cells missing (GCM) domain family | 2 | 2 |
2.1 | Zinc-coordinating group | 106 | MH1 domain family | 3 | 3 |
2.1 | Zinc-coordinating group | 114 | Non methyl-CpG-binding CXXC domain | 2 | 4 |
2.1 | Zinc-coordinating group | 999 | No family level classification | 2 | 2 |
3 | Zipper-type group | 21 | Leucine zipper family | 41 | 64 |
3 | Zipper-type group | 22 | Helix-loop-helix family | 71 | 71 |
4 | Other alpha-helix group | 28 | High mobility group (Box) family | 24 | 28 |
4 | Other alpha-helix group | 29 | MADS box family | 4 | 4 |
4 | Other alpha-helix group | 107 | Sand domain family | 3 | 3 |
4 | Other alpha-helix group | 115 | NF-Y CCAAT-binding protein family | 2 | 2 |
5 | Beta-sheet group | 30 | TATA box-binding family | 1 | 2 |
6 | Beta-hairpin-ribbon group | 34 | Transcription factor T-domain | 11 | 11 |
6 | Beta-hairpin-ribbon group | 108 | Methyl-CpG-binding domain, MBD family | 2 | 2 |
7 | Other | 37 | Rel homology region family | 10 | 10 |
7 | Other | 38 | Stat protein family | 6 | 6 |
7 | Other | 110 | Runt domain family | 3 | 3 |
7 | Other | 112 | Beta_Trefoil-like domain family | 2 | 2 |
7 | Other | 113 | DNA-binding LAG-1-like domain family | 2 | 2 |
8 | Enzyme group | 47 | DNA polymerase-beta family | 1 | 7 |
999 | Unclassified structure | 901 | CP2 transcription factor domain family | 3 | 3 |
999 | Unclassified structure | 902 | AF-4 protein family | 1 | 1 |
999 | Unclassified structure | 903 | DNA binding homeobox and different transcription factors (DDT) domain family | 1 | 1 |
999 | Unclassified structure | 904 | AT-hook domain family | 3 | 6 |
999 | Unclassified structure | 905 | Nuclear factor I - CCAAT-binding transcription factor (NFI-CTF) family | 3 | 3 |