Assignment of isochores for all completely sequenced vertebrate genomes using a consensus

Table 2 The amount of genomic DNA in which methods agree (%)

	IsoFinder	GC-Profile	BASIO	Least-squares	Consensus	Average*
IsoFinder	100.0	62.2	74.8	58.8	82.3	65.3
GC-Profile	62.2	100.0	59.9	83.1	72.8	68.4
BASIO	74.8	59.9	100.0	60.9	85.5	65.2
Least-squares	58.8	83.1	60.9	100.0	73.7	67.6
Consensus	82.3	72.8	85.5	73.7	100.0	78.6

Percentage of the human genome classified into the same isochore families by each pair of methods. The amount of equally classified human DNA ranges from 59-86% in an all-against-all pairwise comparison. On average, all methods agree in about 66% of the genome. The consensus isochore map has the best agreement of 79%, on average, with all other methods. *The average agreement of the method in the respective row with all other methods except itself and the consensus isochore map.

ISSN: 1474-760X