Table 3 Mouse SuperArray data showing greater than twofold cell stress RNA expression changes in the cerebellum of Wldsmice compared with wild-type controls
Gene name | Symbol | Acc. number | Array cell | Fold change | SD | Cell stress and toxicity function |
|---|---|---|---|---|---|---|
Serine (or cysteine) peptidase inhibitor, clade E, member 1 | Serpine1 | NM_008871 | G01 | 3.73 | 0.29 | Inflammation |
Interleukin 1 beta | Il1b | NM_008361 | E11 | 3.69 | 0.82 | Inflammation |
Transformed mouse 3T3 cell double minute 2 | Mdm2 | NM_010786 | F02 | 3.34 | 0.15 | Growth arrest and senescence |
Cytochrome P450, family 2, subfamily a, polypeptide 5 | Cyp2a5 | NM_007812 | B08 | 2.92 | 0.48 | Oxidative or metabolic stress |
Fas ligand (TNF superfamily, member 6) | Fasl | NM_010177 | C11 | 2.62 | 0.71 | Apoptosis signaling |
Bcl2-like 1 | Bcl2l1 | NM_009743 | A04 | -2.11 | 0.25 | Apoptosis signaling |
Cyclin C | Ccnc | NM_016746 | A10 | -2.44 | 0.46 | Proliferation and carcinogenesis |
Chemokine (C-C motif) ligand 21b | Ccl21b | NM_011124 | A07 | -3.37 | 0.25 | Inflammation |
Chemokine (C-C motif) ligand 4 | Ccl4 | NM_013652 | A09 | -3.86 | 0.40 | Inflammation |
Annexin A5 | Anxa5 | NM_009673 | A01 | -4.00 | 1.50 | Apoptosis signaling |
Ataxia telangiectasia mutated homolog (human) | Atm | NM_007499 | A02 | -4.99 | 0.70 | DNA damage and repair |
Caspase 1 | Casp1 | NM_009807 | A05 | -6.81 | 7.58 | Apoptosis signaling |
Cytochrome P450, family 3, subfamily a, polypeptide 11 | Cyp3a11 | NM_007818 | B12 | -8.60 | 0.52 | Oxidative or metabolic stress |
Chemokine (C-C motif) ligand 3 | Ccl3 | NM_011337 | A08 | -9.50 | 2.39 | Inflammation |