Figure 10

NAD-induced changes in cell cycle genes mimic Wld^s-induced changes. (a) Bar chart showing greater than twofold changes in cell cycle genes from SuperArray experiments on Wld^scerebellum (black bars; see Table 1) compared with nicotinamide adenine dinucleotide (NAD) treated HEK293 cells (white bars; see Table 2). Of the nine genes examined, eight responded similarly in both experimental groups. (b) Bar chart showing percentage difference in protein expression in NSC34 cells treated with 1 mmol/l exogenous NAD as compared with control-treated cells.