Table 1 Estrogen-regulated probe sets that are differentially expressed in wounds from elderly compared to young subjects
From: Estrogen, not intrinsic aging, is the major regulator of delayed human wound healing in the elderly
Affy ID | Gene* | Gene (description) | Function | q-value†| FC‡ |
|---|---|---|---|---|---|
Down-regulated probe sets (65) | Â | Â | Â | Â | Â |
   207720_at | LOR | loricrin | Major cornified envelope protein | 0 | -235 |
   201909_at | RPS4Y1 | ribosomal protein S4, Y-linked 1 | 40S ribosomal component | 0 | -142 |
   215704_at | FLG | filaggrin | Cornified envelope-keratin linker | 9.4E-13 | -114 |
   206177_s_at | ARG1 | arginase, liver | Delayed healing-associated | 9.2E-11 | -82.0 |
   206643_at | HAL | histidine ammonia-lyase | Histidine catabolism | 1.5E-10 | -59.0 |
   206421_s_at | SERPINB7 | serpin peptidase inhibitor, clade B (ovalbumin), member 7 | Proteinase inhibitor for plasmin | 5.9E-13 | -47.6 |
   206192_at | CDSN | Corneodesmosin | Desquamation/adhesion | 2.5E-06 | -30.1 |
   213796_at | SPRR1A | small proline-rich protein 1A | Cornified envelope precursor protein | 1.5E-05 | -29.4 |
   207324_s_at | DSC1 | desmocollin 1 | Desmosomal cadherin/adhesion | 9.6E-06 | -28.9 |
   209719_x_at | SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | Inflammation and cancer-associated | 1.6E-05 | -22.4 |
   217496_s_at | IDE | insulin-degrading enzyme | Wound fluid/resolution of insulin response | 4.0E-06 | -20.5 |
   211597_s_at | HOP | homeodomain-only protein | Serum response factor binding | 1.7E-04 | -19.7 |
   211726_s_at | FMO2 | flavin containing monooxygenase 2 (non-functional) | Non-functional oxidative enzyme | 7.0E-04 | -18.9 |
   220414_at | CALML5 | calmodulin-like 5 | Epidermal-associated calcium-binding | 2.0E-05 | -17.7 |
   203328_x_at | IDE | insulin-degrading enzyme | Wound fluid/resolution of insulin response | 1.4E-05 | -17.4 |
   210413_x_at | SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | Cancer and inflammation-associated | 3.1E-05 | -15.8 |
   219795_at | SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | Amino acid transport/obesity | 6.9E-04 | -15.6 |
   210074_at | CTSL2 | cathepsin L2 | Lysosomal cysteine proteinase | 3.8E-05 | -15.5 |
   222242_s_at | KLK5 | kallikrein 5 | Desquamation, angiogenesis and cancer | 4.0E-05 | -15.0 |
   201348_at | GPX3 | glutathione peroxidase 3 (plasma) | Protection from oxidative damage | 1.2E-05 | -14.8 |
   202018_s_at | LTF | lactotransferrin | Inflammatory-cell-derived antioxidant | 4.6E-02 | -14.5 |
   205185_at | SPINK5 | serine peptidase inhibitor, Kazal type 5 | Anti-inflammatory/anti-microbial | 3.8E-05 | -14.4 |
   211906_s_at | SERPINB4 | serpin peptidase inhibitor, clade B (ovalbumin), member 4 | Cancer and inflammation-associated | 5.7E-05 | -12.4 |
   219232_s_at | EGLN3 | egl nine homolog 3 (C. elegans) | Hypoxia-inducible apoptosis-inducing | 1.4E-05 | -12.1 |
   213256_at | MARCH3 | membrane-associated ring finger (C3HC4) 3 | Poorly characterized ubiquitin ligase | 1.6E-05 | -12.1 |
   204733_at | KLK6 | kallikrein 6 (neurosin, zyme) | Hormone regulated serine protease | 1.4E-05 | -11.9 |
   202179_at | BLMH | bleomycin hydrolase | Cysteine peptidase | 2.1E-03 | -11.8 |
   214549_x_at | SPRR1A | small proline-rich protein 1A | Cornified envelope precursor protein | 1.6E-04 | -11.3 |
   207908_at | KRT2 | keratin 2 (epidermal ichthyosis bullosa of Siemens) | Supra-basally expressed cytokeratin | 1.2E-03 | -11.1 |
   210338_s_at | HSPA8 | heat shock 70 kDa protein 8 | ERalpha-inhibiting heat shock protein | 9.9E-04 | -10.6 |
   209720_s_at | SERPINB3 | serpin peptidase inhibitor, clade B (ovalbumin), member 3 | Inflammation and cancer-associated | 3.3E-04 | -10.5 |
   201849_at | BNIP3 | BCL2/adenovirus E1B 19 kDa interacting protein 3 | Mitochondrial apoptosis-inducing | 2.7E-04 | -10.1 |
   205916_at | S100A7 | S100 calcium binding protein A7 | Chemotactic psoriasis-associated protein | 1.7E-04 | -10.0 |
   204952_at | LYPD3 | LY6/PLAUR domain containing 3 | Upregulated in migrating keratinocytes | 1.2E-03 | -9.7 |
   206595_at | CST6 | cystatin E/M | Cysteine protease inhibitor | 1.7E-06 | -9.3 |
   203327_at | IDE | insulin-degrading enzyme | Wound fluid/resolution of insulin response | 7.0E-04 | -9.3 |
   209555_s_at | CD36 | CD36 molecule | Thrombospondin receptor | 4.0E-03 | -9.2 |
   219532_at | ELOVL4 | elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4 | Skin barrier-promoting fatty acid elongase | 1.5E-05 | -9.2 |
   209126_x_at | KRT6B | keratin 6B | Injury-associated keratin | 1.7E-03 | -9.1 |
   212573_at | ENDOD1 | endonuclease domain containing 1 | Unknown | 8.3E-04 | -9.0 |
   214599_at | IVL | involucrin | Early cornified envelope protein | 2.8E-03 | -8.8 |
   209218_at | SQLE | squalene epoxidase | Rate-limiting sterol biosynthesis enzyme | 7.2E-04 | -8.8 |
   207356_at | DEFB4 | defensin, beta 4 | Antimicrobial peptide | 6.0E-03 | -8.8 |
   210138_at | RGS20 | regulator of G-protein signaling 20 | GTPase-activating protein | 8.1E-04 | -8.7 |
   202504_at | TRIM29 | tripartite motif-containing 29 | Cancer-associated transcription factor | 2.2E-03 | -8.6 |
   205016_at | TGFA | transforming growth factor, alpha | IFN-induced/epidermal regeneration | 1.0E-03 | -8.5 |
   209309_at | AZGP1 | alpha-2-glycoprotein 1, zinc | TNFA-regulated prostate-cancer marker | 3.5E-04 | -8.5 |
   209800_at | KRT16 | keratin 16 (focal non-epidermolytic palmoplantar keratoderma) | Hyperproliferation and healing-associated keratin | 1.2E-03 | -8.3 |
   205778_at | KLK7 | kallikrein 7 (chymotryptic, stratum corneum) | Innate immunity/desquamation | 1.2E-05 | -8.3 |
   219756_s_at | POF1B | premature ovarian failure, 1B | Unknown | 3.9E-05 | -8.1 |
   214091_s_at | GPX3 | glutathione peroxidase 3 (plasma) | Protection from oxidative damage | 3.0E-03 | -8.1 |
   203585_at | ZNF185 | zinc finger protein 185 (LIM domain) | Actin-associated tumor suppressor | 1.4E-03 | -8.1 |
   206008_at | TGM1 | transglutaminase 1 | CE formation/epidermal differentiation | 4.6E-05 | -8.0 |
   202037_s_at | SFRP1 | secreted frizzled-related protein 1 | Repressor of WNT signaling | 6.6E-04 | -7.9 |
   202539_s_at | HMGCR | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase | Rate-limiting cholesterol synthesis enzyme | 7.4E-04 | -7.8 |
   203575_at | CSNK2A2 | casein kinase 2, alpha prime polypeptide | p53 phosphorylation, WNT signaling | 4.6E-04 | -7.7 |
   206884_s_at | SCEL | sciellin | Cornified envelope precursor protein | 2.1E-04 | -7.5 |
   204284_at | PPP1R3C | protein phosphatase 1, regulatory (inhibitor) subunit 3C | Regulates a wide variety of cellular functions | 9.9E-04 | -7.4 |
   266_s_at | CD24 | CD24 molecule | Marker for epithelial neoplasms | 2.7E-04 | -7.4 |
   203914_x_at | HPGD | hydroxyprostaglandin dehydrogenase 15-(NAD) | Main enzyme for prostaglandin degradation | 1.6E-04 | -7.3 |
   219410_at | TMEM45A | transmembrane protein 45A | Hox-regulated/reproductive tissue expressed | 8.1E-04 | -7.3 |
   206488_s_at | CD36 | CD36 molecule | Thrombospondin receptor | 1.2E-05 | -7.3 |
   204881_s_at | UGCG | UDP-glucose ceramide glucosyltransferase | Keratinocyte glucosyltransferase | 1.8E-03 | -7.1 |
   213933_at | PTGER3 | prostaglandin E receptor 3 (subtype EP3) | Impaired wound healing in null mouse | 8.3E-04 | -7.1 |
   216379_x_at | CD24 | CD24 molecule | Marker for epithelial neoplasms | 7.9E-04 | -7.0 |
Up-regulated probe sets (8) | Â | Â | Â | Â | Â |
   221728_x_at | XIST | X (inactive)-specific transcript | X chromosome inactivation | 2.4E-12 | 191.8 |
   214218_s_at | XIST | X (inactive)-specific transcript | X chromosome inactivation | 1.0E-09 | 56.2 |
   206211_at | SELE | selectin E (endothelial adhesion molecule 1) | Endothelial-leukocyte adhesion | 9.0E-02 | 8.5 |
   211600_at | PTPRO | protein tyrosine phosphatase, receptor type, O | New marker of podocyte injury | 5.0E-04 | 8.4 |
   220940_at | KIAA1641 | KIAA1641 | Unknown | 1.0E-04 | 8.3 |
   203915_at | CXCL9 | chemokine (C-X-C motif) ligand 9 | Interferon induced, TH1 response | 6.3E-02 | 7.3 |
   204324_s_at | GOLPH4 | golgi phosphoprotein 4 | Protein export | 8.3E-04 | 7.3 |
   201205_at | RRBP1 | ribosome binding protein 1 homolog 180 kDa (dog) | Developmentally regulated extracellular matrix glycoprotein | 6.3E-03 | 7.3 |