Table 1 Characteristics of Sme efflux transporters in S. maltophilia K279a
Systematic ID | Name | Known or putative regulation mechanism | Closest match to a known antimicrobial efflux protein |
|---|---|---|---|
Smlt4474-4476 | SmeABC | Two component regulator (SmeSR, Smlt4477-8) | S. maltophilia SmeABC [20] |
Smlt4070-4072 | SmeDEF | Tet-R type (SmeT, Smlt4073) | S. maltophilia SmeDEF [17,22] |
Smlt1829-1833 | SmeVWX | LysR type (Smlt1827) | 51%, 56% and 48% amino acid identity, respectively, to P. aeruginosa MexEF-OprN [64] |
Smlt2201-2202 | SmeYZ | Two component regulator (Smlt2199-30) | 44% and 59% amino acid identity, respectively, to AdeAB of A. baumanii [65] |
Smlt3170-3171 | SmeGH | TetR type (Smlt3169) | 39% and 49% amino acid identity, respectively, to AcrAB of M. morganii [66] |
Smlt3788-3787 | SmeMN | ? | <30% identity to other known antimicrobial efflux proteins |
Smlt3925-3924 | SmeOP | TetR type (Smlt3926) | <30% identity to other known antimicrobial efflux proteins |
Smlt4279/4281 | SmeIJK | ? | 41%, 50% and 44% amino acid identity, respectively, to MtdABC of E. coli [25] |