Functional diversification of duplicate genes through subcellular adaptation of encoded proteins

Table 1 Subcellular localization data for S. cerevisiae proteins in this study

	Number of S. cerevisiae proteins*	Number of WGD duplicate pairs^†	Number of WGD pairs with distinct localizations for the two members
GFP tagging^‡	3,919 (62.9%)	238 (52.8%)	88 (37.0%)
Epitope tagging^§	2,745 (44.0%)	124 (27.5%)	53 (42.7%)
GFP/epitope tagging overlap^¶	2,716 (43.5%)	75 (16.7%)	18 (24%)

*Out of 6,234 annotated yeast open reading frames [15]. ^†Out of 450 gene pairs [17]. ^‡Based on [15] unambiguous protein localization assigments. ^§Based on [19]. ^¶Gene pairs for which the subcellular localization is unambiguously assigned to both paralogs in both datasets.

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