From: KEGG spider: interpretation of genomics data in the context of the global gene metabolic network
 |  | Input proteins/genes | GENECODIS | KEGG spider | ||||
---|---|---|---|---|---|---|---|---|
Paper | Table | All | KEGG | k | max | Model | n | P-value |
Proteomic analysis of primary cell lines identifies protein changes present in renal cell carcinoma [40] | Table 1: proteins found to be differentially expressed between matched normal and RCC primary lines | 62 | 23 | 5 | 10 | D 3 | 22 | <0.01 |
Proteomic analysis of anaplastic lymphoma cell lines: identification of potential tumour markers [41] | Table 2: proteins overexpressed in FE-PD cells compared to SU-DHL-1 cells | 41 | 13 | 3 | 3 | D 2 | 12 | 0.015 |
Differential expression profiling of human pancreatic adenocarcinoma and healthy pancreatic tissue [42] | Table 3: proteins at higher levels in normal pancreas compared to pancreatic cancer | 40 | 12 | 2 | 5 | D 3 | 12 | 0.015 |
Proteomic search for potential diagnostic markers and therapeutic targets for ovarian clear cell adenocarcinoma [43] | Table 1: differentially expressed proteins in human ovarian cancer cells | 36 | 17 | 3 | 4 | D 2 | 13 | 0.025 |
Quantitative proteomic analysis to discover potential diagnostic markers and therapeutic targets in human renal cell carcinoma [44] | Table 3: differentially expressed proteins in RCC patients | 91 | 36 | 12 | 14 | D 2 | 33 | <0.001 |
Protein profile changes in the human breast cancer cell line MCF-7 in response to SEL1L [45] | Table 4: MCF7-SEL1L differentially expressed genes identified by microarray analysis | 60 | 9 | 1 | 4 | D 2 | 7 | 0.03 |
Protein dysregulation in mouse hippocampus polytransgenic for chromosome 21 structures in the Down syndrome critical region [46] | Table 2: list of proteins dysregulated in hippocampus of polytransgenic micea | 42 | 14 | 2 | 5 | D 2 | 12 | 0.015 |
Differential expression of proteins in response to ceramide-mediated stress signal in colon cancer cells by 2-D gel electrophoresis and MALDI-TOF-MS [47] | Table 1: list of identified proteins on HCT116 2-DE gels | 82 | 16 | 2 | 4 | D 3 | 15 | 0.02 |
Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells [48] | Table 2: functional classifications of the deregulated proteins in NSC606985-induced apoptotic NB4 Cellsa | 88 | 15 | 1 | 5 | D 3 | 15 | <0.001 |
Proteome analysis of responses to ascochlorin in a human osteosarcoma cell line by 2-D gel electrophoresis and MALDI-TOF MS [49] | Table 2: differentially expressed proteins in ascochlorin-treated U2OS cells | 87 | 13 | 3 | 5 | D 2 | 12 | <0.001 |
Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells [50] | Table 1: summary of differentially expressed proteins and their functional classifications | 227 | 59 | 11 | 9 | D 3 | 54 | <0.001 |
Proteomic analysis of the resistance to aplidin in human cancer cells [51] | Table 1: differentially expressed proteins between resistant and wild-type HeLa cells identified in the membrane fraction | 26 | 8 | 5 | 3 | D 2 | 6 | 0.02 |
Proteomic analysis of the resistance to aplidin in human cancer cells [51] | Table 2: differentially expressed proteins between resistant and wild-type HeLa cells identified in the cytosolic fraction | 37 | 11 | 5 | 7 | D 2 | 11 | 0.015 |
Identification of specific protein markers in microdissected hepatocellular carcinoma | Table 2: identified proteins from HCC and nontumorous liver tissue by in-gel digestion and SELDI-MS | 51 | 20 | 8 | 4 | D 2 | 17 | 0.015 |
Comparison of membrane-associated proteins in human cholangiocarcinoma and hepatocellular carcinoma cell lines [52] | Table 1: list of proteins from the membrane fraction of HuCCA-1 and HCC-S102 cell lines which show up-regulated expression | 56 | 11 | 2 | 5 | D 3 | 11 | <0.001 |
Contribution of laser microdissection-based technology to proteomic analysis in hepatocellular carcinoma developing on cirrhosis [53] | Table 1: proteins differentially expressed in tumorous LM-hepatocytes and total homogenates samples identified PMF | 43 | 20 | 0 | 0 | D 3 | 18 | 0.04 |
Proteome alterations induced in human white blood cells by consumption of Brussels sprouts: results of a pilot intervention study [54] | Table 1: protein alterations induced by a controlled dietary intervention with Brussels sprouts in human primary white blood cells | 44 | 17 | 2 | 4 | D 2 | 12 | <0.05 |