Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression

Table 3 Two group comparisons examined for each of the GEO datasets

Dataset	Condition 1	Condition 2	No. of samples in condition 1	No. of samples in condition 2	Significant dataset
GSE3320	Non smokers	Smokers	5	6	*
GSE2302	Control	Smoke 15 min, 24 hr recovery	9	5	**
GSE2302	Control	Smoke 15 min, 4 and 24 hr recovery	9	9	*
GSE2302	Control	Smoke 15 min, 4 hr recovery	9	4	**
GSE1276	Untreated, 2 and 4 h S9+CSCA/CSCB	8 and 12 h S9+CSCA/CSCB	10	8	*
GSE1276	S9 2, 4, 8 and 12 h	S9+CSCA 2, 4, 8, 12 h	8	8
GSE1276	S9 2, 4, 8 and 12 h	S9+CSCB 2, 4, 8, 12 h	8	8
GSE1815	Untreated 8 and 24 h	INF-gamma treated 24 h	9	5	**
GSE1815	Untreated 8 and 24 h	INF-gamma treated 8 and 24 h	9	9	*
GSE2111	Control	Zinc sulfate	4	4	*
GSE2111	Control	Vanadium	4	4
GSE5264	Days 0 through 8	Days 10 through 28	14	16	*
GSE620	Control	4-PBA 12 and 24 h	5	6	*
GSE620	Control	4-PBA 24 h	5	3	**
GSE3397	Control	RSV 24 h	4	4
GSE3397	Control	RSV 4 and 24 h	4	8	*
GSE3183	Control	IL13 4, 12, and 24 h	6	9
GSE3183	Control	IL13 24 h	6	3
GSE3183	Control + IL13 4 h	IL13 12 and 24 h	9	6	*
GSE3004	Pre-allergen challenge	Post-allergen challenge	5	5

The GEO series accessions as well as the description and numbers of samples in each of the conditions are listed for each comparison. Datasets where genes differentially expressed between condition 1 and condition 2 demonstrated similarity to genes differentially expressed between current and never smokers in our dataset are indicated by the presence of one or two asterisks. Only comparisons indicated by a single asterisk are shown in Figure 5. S9, rat S9 microsomal fraction; CSC, cigarette smoke condensate; INF-gamma, interferon gamma; 4-PBA, 4-phenylbutyrate; RSV, respiratory syncytial virus; IL13, interleukin 13.

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