Reversible and permanent effects of tobacco smoke exposure on airway epithelial gene expression

Table 2 EASE analysis results

System	Category	EASE score	Permutation P value	Reversibility group
GO molecular function	Oxidoreductase activity	8.49E-08	1.00E-03	Rapidly reversible genes
GO molecular function	Electron transporter activity	4.60E-06	1.00E-03	Rapidly reversible genes
GenMAPP pathway	Homo sapienspentose phosphate pathway	8.59E-06	1.00E-03	Rapidly reversible genes
GO molecular function	Oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	5.73E-05	2.00E-03	Rapidly reversible genes
GO molecular function	Oxidoreductase activity, acting on CH-OH group of donors	7.59E-05	2.00E-03	Rapidly reversible genes
KEGG Pathway	Carbohydrate metabolism - Homo sapiens	1.71E-04	4.00E-03	Rapidly reversible genes
Chromosomal location	16q13	2.02E-03	1.00E-03	Slowly reversible and irreversible genes

EASE was used to identify GO molecular function categories, KEGG pathways, GenMAPP pathways, and chromosomal locations over-represented (Permutation P ≤ 0.01) among genes designated as slowly reversible and irreversible or rapidly reversible compared to all annotated genes on the Affymetrix U133A microarray.

ISSN: 1474-760X