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Figure 4 | Genome Biology

Figure 4

From: Disruption and pseudoautosomal localization of the major histocompatibility complex in monotremes

Figure 4

Phylogenetic analysis of platypus MHC class I genes. (a) Species tree of taxonomic entities represented in the trees shown in Figures 3 and 4b. (b) MHC class I gene phylogenetic tree. Hosa, Homo sapiens (human); Eqca, Equus caballus (horse); Cafa, Canis familiaris (dog); Tube, Tupaia belangeri (Northern tree shrew); Orcu, Oryctolagus cuniculus (rabbit); Rano, Rattus norvegicus (rat); Modo, Monodelphis domestica (opossum); Isma, Isoodon macrourus (Northern brown bandicoot); Trvu, Trichosurus vulpecula (silver-grey brushtail possum); Maru, Macropus rufogriseus (red-necked wallaby); Maeu, Macropus eugenii (tammar wallaby); Oran, Ornithorhynchus anatinus (platypus); Taac, Tachyglossus aculeatus (echidna); Anpl, Anas platyrhynchos (duck); Gaga, Gallus gallus (chicken); Pesi, Pelodiscus sinensis (Chinese softshell turtle); Amam, Ameiva ameiva (lizard); Nesi, Nerodia sipedon (snake); Sppu, Sphenodon punctatus (tuatara); Amme, Ambystoma mexicanum (axolotl); Rapi, Rana pipiens (Northern leopard frog); Xela, Xenopus laevis (African clawed frog); Xetr, Xenopus tropicalis (Western clawed frog). Black diamonds highlight platypus class I sequences identified in this study. The marsupial Isoodon (Isma2-1-3) is represented by an artificial class I sequence that we generated from three separate overlapping class I sequence entries for this species. Tree construction using the NJ method was as described in Materials and methods. Numbers indicate bootstrap support in percent. Branch lengths are proportional to number of substitutions. The scale bar indicates 10% substitutions per site. Sequences used and their accession numbers are listed in Additional data file 11.

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