Exon expression profiling reveals stimulus-mediated exon use in neural cells

Table 2 Distribution of exons exhibiting alternative splice site choice in RefSeq transcripts and in the Exon datasets

Exon position	Type of alternative splice choice	Percentage in RefSeq database	Percentage in KCl exon	P value	Percentage in TPG exon	P value
Initial	5'	24.32	28.14	1.367 × e^-03*	27.70	8.081 × e^-05*
Initial	Alternative start	25.25	27.18	6.386 × e^-02*	30.07	6.674 × e^-08*
Internal	5'	5.31	8.02	1.179 × e^-13*	6.53	4.935 × e^-11*
Internal	3'	5.32	8.05	8.393 × e^-14*	6.77	9.659 × e^-15*
Final	Alternative termination	23.43	25.63	1.574 × e^-02*	28.55	1.110 × e^-16*
Final	3'	22.92	23.27	3.515 × e^-01	24.83	7.685 × e^-04*

RefSeq exons were classified as exhibiting 5' or 3' alternative splice site choice according their presence in RefSeq transcripts. Constituents of the potassium chloride (KCl) and thapsigargin (TPG) exon datasets were mapped to these definitions. *P values showing statistical significance for enrichment of alternative splice site choice exons at initial, internal, and final positions through a binomial test.

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