Table 3 Comparison of theoretical gene essentiality predictions with results of TraSH experiment in vitro
From: GSMN-TB: a web-based genome-scale network model of Mycobacterium tuberculosismetabolism
| Â | TraSH threshold of 0.2 | TraSH threshold of 0.1 | TraSH threshold of 0.1, altered energetic parameters |
|---|---|---|---|
True positive | 154 | 115 | 114 |
False positive | 71 | 110 | 110 |
True negative | 385 | 432 | 432 |
False negative | 95 | 48 | 49 |
Sensitivity | 62% | 71% | 70% |
Specificity | 84% | 80% | 80% |
Correct predictions | 76% | 78% | 77% |
P a | < 2.2 × 10-16 | < 2.2 × 10-16 | < 2.2 × 10-16 |