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Table 2 Significant pathways for TGF-β gene signatures

From: Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis

Pathway TFs Significant TFs P value
Yang et al. gene signature    
   AhR AhR, ER-α, Sp1, p300, NF-κB, Arnt AhR, Sp1, p300, NF-κB, Arnt <0.001
   EGF c-Fos, Elk-1, Sp1, STAT3, c-Jun, STAT1α, c-Myc Sp1, c-Jun, c-Myc <0.001
   c-Kit MITF, Sp1, Tal-1, p300, GATA-1 Sp1, p300 <0.001
   p53 TFIIA, E2F1, p53, p300, BRCA1, YY1 E2F1, p53, p300, BRCA1 <0.001
   Caspases CREB, Max, SRF, p53, AP-2α CREB, Max, p53, AP-2α <0.001
   MAPK CREB, Elk-1, p53, c-Jun, c-Myc CREB, p53, c-Jun, c-Myc <0.001
   E2F DP-1, E2F, p53 DP-1, E2F, p53 <0.001
   HIF-1 p53, p300, HIF-1α, HNF-4α2, Arnt p53, p300, HIF-1α, Arnt <0.001
   Stress PPAR-γ, c-Ets-1, PPAR-α, Max NF-AT2, HSF1, c-Jun, Elk-1, p53, CHOP-10, CREB, CRE-BP2, RXR-α, HNF-1α, STAT3, MRF4 Max, c-Jun, p53, CREB, CRE-BP2, RXR-α 0.001
   TLR3 CRE-BP2, p300, c-Jun, IRF-3, IRF-7, NF-κB CRE-BP2, p300, c-Jun, NF-κB 0.002
   TLR4 CREB, CRE-BP2, STAT1, Elk-1, p300, IRF-3, IRF-7, NF-κB CREB, CRE-BP2, p300, NF-κB 0.002
   p38 ELk-1, p53, MITF, PPAR-α, CHOP-10, Max, CREB, PU.1, HNF-1α, CRE-BP2, NF-AT2, STAT3, MRF4 p53, Max, CREB, CRE-BP2 0.003
   JNK CRE-BP2, p53, HSF1, PPAR-γ, STAT3, c-Jun, c-Ets-1 CRE-BP2, p53, c-Jun 0.004
   TGF-β LEF-1, CRE-BP2, Smad2, Smad3, Smad4 CRE-BP2, Smad4 0.006
   EDAR c-Jun, NF-κB c-Jun, NF-κB 0.015
   IL-1 ELk-1, c-Jun, NF-κB c-Jun, NF-κB 0.015
   TCR2 c-Jun, NF-κB, NF-AT c-Jun, NF-κB 0.018
   RANK MITF, PU.1, c-Jun, NF-κB c-Jun, NF-κB 0.020
   Hypoxia ER-α, p53, AP-1, HIF-1α p53, HIF-1α 0.033
   Notch Max, LEF-1, p300, c-Myc Max, p300, c-Myc 0.037
Karlsson et al . gene signature    
   AhR AhR, ER-α, Sp1, p300, NF-κB, Arnt AhR, Sp1, Arnt <0.001
   EGF c-Fos, Elk-1, Sp1, STAT3, c-Jun, STAT1α, c-Myc Sp1, STAT1α, c-Myc <0.001
   c-Kit MITF, Sp1, Tal-1, p300, GATA-1 Sp1, Tal-1 <0.001
   p53 TFIIA, E2F1, p53, p300, BRCA1, YY1 E2F1, BRCA1 <0.001
   Caspases CREB, Max, SRF, p53, AP-2α Max, AP-2α <0.001
   E2F DP-1, E2F, p53 DP-1, E2F 0.002
   HIF-1 p53, p300, HIF-1α, HNF-4α2, Arnt HIF-1α, Arnt 0.006
   Notch Max, LEF-1, p300, c-Myc Max, c-Myc 0.019