Pathway | TFs | Significant TFs | P value |
---|---|---|---|
E2F3 gene signature | |||
E2F | DP-1, E2F, p53 | DP-1, E2F | <0.001 |
Caspases | CREB, Max, SRF, p53, AP-2α | AP-2α | <0.001 |
Myc gene signature | |||
AhR | AhR, ER-α, Sp1, p300, NF-κB, Arnt | AhR, Sp1, NF-κB, Arnt | <0.001 |
HIF-1 | p53, p300, HIF-1α, HNF-4α2, Arnt | HIF-1α, Arnt | <0.001 |
Notch | Max, LEF-1, p300, c-Myc | Max, c-Myc | <0.001 |
EGF | c-Fos, Elk-1, Sp1, STAT3, c-Jun, STAT1α, c-Myc | Sp1, c-Myc | 0.002 |
Caspases | CREB, Max, SRF, p53, AP-2α | Max, AP-2α | 0.002 |
c-Kit | MITF, Sp1, Tal-1, p300, GATA-1 | MITF, Sp1, Tal-1 | 0.006 |
Ras gene signature | |||
AhR | AhR, ER-α, Sp1, p300, NF-κB, Arnt | Sp1, NF-κB | <0.001 |
Apoptosis | p53, FOXO3a, NF-κB | p53, NF-κB | 0.001 |
Caspases | CREB, Max, SRF, p53, AP-2α | CREB, p53, AP-2α | 0.004 |
RANK | MITF, PU.1, c-Jun, NF-κB | PU.1, NF-κB | 0.008 |
TNFα | AP-1, NF-κB | AP-1, NF-κB | 0.009 |
TLR4 | CREB, CRE-BP2, STAT1, Elk-1, p300, IRF-3, IRF-7, NF-κB | CREB, CRE-BP2, NF-κB | 0.015 |
MAPK | CREB, Elk-1, p53, c-Jun, c-Myc | CREB, p53 | 0.023 |
TLR3 | CRE-BP2, p300, c-Jun, IRF-3, IRF-7, NF-κB | CRE-BP2, NF-κB | 0.034 |
p38 | ELk-1, p53, MITF, PPAR-α, CHOP-10, Max, CREB, PU.1, MRF4, HNF-1α, CRE-BP2, NF-AT2, STAT3 | p53, PPAR-α, CHOP-10, CREB, PU.1, CRE-BP2 | 0.035 |
Stress | PPAR-γ, c-Ets-1, PPAR-α, Max, NF-AT2, HSF1, c-Jun, Elk-1, p53, CHOP-10, CREB, CRE-BP2, RXR-α, HNF-1α, STAT3, MRF4 | PPAR-α, p53, CHOP-10, CREB, CRE-BP2 | 0.037 |