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Table 1 Significant pathways for oncogenic gene signatures

From: Revealing signaling pathway deregulation by using gene expression signatures and regulatory motif analysis

Pathway

TFs

Significant TFs

P value

E2F3 gene signature

   

   E2F

DP-1, E2F, p53

DP-1, E2F

<0.001

   Caspases

CREB, Max, SRF, p53, AP-2α

AP-2α

<0.001

Myc gene signature

   

   AhR

AhR, ER-α, Sp1, p300, NF-κB, Arnt

AhR, Sp1, NF-κB, Arnt

<0.001

   HIF-1

p53, p300, HIF-1α, HNF-4α2, Arnt

HIF-1α, Arnt

<0.001

   Notch

Max, LEF-1, p300, c-Myc

Max, c-Myc

<0.001

   EGF

c-Fos, Elk-1, Sp1, STAT3, c-Jun, STAT1α, c-Myc

Sp1, c-Myc

0.002

   Caspases

CREB, Max, SRF, p53, AP-2α

Max, AP-2α

0.002

   c-Kit

MITF, Sp1, Tal-1, p300, GATA-1

MITF, Sp1, Tal-1

0.006

Ras gene signature

   

   AhR

AhR, ER-α, Sp1, p300, NF-κB, Arnt

Sp1, NF-κB

<0.001

   Apoptosis

p53, FOXO3a, NF-κB

p53, NF-κB

0.001

   Caspases

CREB, Max, SRF, p53, AP-2α

CREB, p53, AP-2α

0.004

   RANK

MITF, PU.1, c-Jun, NF-κB

PU.1, NF-κB

0.008

   TNFα

AP-1, NF-κB

AP-1, NF-κB

0.009

   TLR4

CREB, CRE-BP2, STAT1, Elk-1, p300, IRF-3, IRF-7, NF-κB

CREB, CRE-BP2, NF-κB

0.015

   MAPK

CREB, Elk-1, p53, c-Jun, c-Myc

CREB, p53

0.023

   TLR3

CRE-BP2, p300, c-Jun, IRF-3, IRF-7, NF-κB

CRE-BP2, NF-κB

0.034

   p38

ELk-1, p53, MITF, PPAR-α, CHOP-10, Max, CREB, PU.1, MRF4, HNF-1α, CRE-BP2, NF-AT2, STAT3

p53, PPAR-α, CHOP-10, CREB, PU.1, CRE-BP2

0.035

   Stress

PPAR-γ, c-Ets-1, PPAR-α, Max, NF-AT2, HSF1, c-Jun, Elk-1, p53, CHOP-10, CREB, CRE-BP2, RXR-α, HNF-1α, STAT3, MRF4

PPAR-α, p53, CHOP-10, CREB, CRE-BP2

0.037