Decline of nucleotide excision repair capacity in aging Caenorhabditis elegans

Table 3 Major biologic functions altered in aging versus young glp-1 adults

Biologic process/molecular function^a	mRNA levels in aging versus young adult glp-1s	Proportion changed^b	P value^b
Larval development	Decreased	112/842	<0.0001
Ion transport	Decreased	113/504	<0.0001
Generation of precursor metabolites and energy	Decreased	78/474	<0.0001
Structural constituents of cuticle	Decreased	88/144	<0.0001
Lipid metabolism	Decreased	24/145	<0.0001
Oxidative phosphorylation	Decreased	13/44	<0.0001
Aging (C elegans)	Decreased	12/58	0.003
Catalytic activity	Decreased	215/2734	0.0004
Glycolysis	Decreased	4/15	0.014
Positive regulation of growth	Increased	124/928	<0.0001
Cytoskeleton	Increased	21/108	0.0003
Rab-related GTPase protein-mediated vesicular trafficking	Increased	16/72	0.0003
Aging (C elegans)	Increased	10/58	0.004
Osmoregulation	Increased	21/137	0.007
Locomotion	Increased	24/144	0.001

Shown are major biologic functions altered in aging (6-day) as compared with young (1-day) glp-1 adults. ^aListed Gene Ontologies were identified as different in young and aging glp-1s in at least two of three different bioinformatic analyses. ^bProportion changed and p values are as determined by GOMiner. Complete Gene Ontology analyses are given in Additional data files 3, 4 (parts A and B), and 5. I changed the format slightly to avoid breaking up "glp-1s".

ISSN: 1474-760X