Figure 7

Most highly expressed TIN transcripts map to genes related to regulation of transcription. TIN RNA expression data from three different human tissues (prostate, liver and kidney) were used to select the protein-coding genes to which the top 40% most highly expressed TIN transcripts map. The BiNGO program was used to identify significantly (p ≤ 0.05) enriched GO terms within the set of selected protein-coding genes. (a) GO-enriched categories for prostate are shown in color, which is related to the p value as indicated by the color-code bar. The exact p values for all significantly enriched GO categories are shown in Additional data file 4. GO category 'Regulation of transcription, DNA-dependent' (GO:006355) is the most significantly enriched (p = 0.002). Similar results were obtained for liver and kidney (see Additional data file 4). (b) Venn diagram for the 123 unique protein-coding genes belonging to GO:006355 category 'Regulation of transcription, DNA-dependent'. The number of genes in each tissue for which intronic transcription was detected is shown in parenthesis; the numbers of coincident and dissimilar genes among kidney, prostate and liver are shown in the circles.