Figure 2

Exact masses and chemical structures of metabolites characterized with the Metlin database. The significance of fold changes between the KO1 versus WT, KO3 versus WT, and DKO versus WT are indicated with an asterisk where p < 0.005. The significance for all 5 metabolites is further increased to p < 0.00001 when comparing KO3 and DKO to KO1 and WT. Average intensity values ± relative standard deviation values are indicated in parentheses below the fold changes, and demonstrate the large difference in metabolite abundance between the five LPC molecules. Structures were obtained from the LipidMaps website [34].