The Homer family proteins

Table 1 Interaction partners of Homer family proteins

Protein	Species	Binding sequence or domain	Amino acids	Binding domain of Homer	References
mGluR1a	Rat	Pro-Pro-Ser-Pro-Phe	1146-1150	EVH1	[1,5,6]
mGluR15	Rat	Pro-Pro-Ser-Pro-Phe	1124-1128	EVH1	[1,5,6]
IP₃ receptor type1	Human	Pro-Pro-Lys-Lys-Phe	49-53	EVH1	[43]
IP₃ receptor type3	Human	Pro-Pro-Lys-Lys-Phe	48-52	EVH1	[43]
Actin	Mouse	ND	ND	EVH1	[7]
Shank1	Rat	Pro-Pro-Lys-Glu-Phe	1566-1570	EVH1	[64]
Shank3	Rat	Pro-Pro-Glu-Glu-Phe	1310-1314	EVH1	[64]
RyR1	Human	Pro-Pro-His-His-Phe	1772-1776	EVH1	[43]
TRPC1	Human	Pro-Pro-Pro-Phe	645-649	EVH1	[65]
PIKE-L	Rat	Pro-Lys-Pro-Phe	187-191	EVH1	[50]
DynaminIII	Human	Pro-Pro-Val-Pro-Phe	799-803	EVH1	[43,66]
Oligophrenin-1	Human	Pro-Pro-Leu-Glu-Phe	4-8	EVH1	[62]
synArfGEF	Rat		874-981	EVH1	[67]
DrebrinE	Mouse	Pro-Pro-Ala-Thr-Phe	546-550	EVH1	[27]
	Mouse	Pro-Pro-Pro-Val-Phe	628-632	EVH1	[27]
Oskar	Drosophila	ND	ND	EVH1	[57]
C/EBPb	Human	Pro-Pro-Pro-Ara-Phe	16-20	EVH1	[68]
Pax6	Human	Carboxy-terminal Pro-Ser-Thr-rich domain	ND	Homer3 lacking N-terminal 70 amino acids	[69]
Syntaxin-13	Mouse	Carboxy-terminal 153 amino acids	1-153	Homer1b carboxy-terminal 190 amino acids	[21]
Homer1b/c	Mouse	Carboxy-terminal CC	175-366	Carboxy-terminal CC	[5,6,20]
Homer1b/c	Mouse	LZ	289-323, 335-363	Homer1b/c LZ	[8,16]
Homer1b/c	Mouse	Ser-Pro-Leu-Thr-Pro (P motif)	138-142	EVH1	[19]
Homer2	Mouse	Carboxy-terminal CC	112-354	Carboxy-terminal CC	[6,8]
Homer3	Mouse	Carboxy-terminal CC	102-358	Carboxy-terminal CC	[8]
Activated Cdc42	Human	ND	ND	Homer2 CC	[7]

Abbreviations: CC, coiled-coil; C/EBP, CCAAT/enhancer binding protein; IP₃, inositol 1,4,5-trisphosphate; LZ, leucine zipper; mGluR, metabotropic glutamate receptor; PIKE-L, phosphoinositide 3 kinase enhancer; RyR, ryanodine receptor; synArfGEF, guanine-nucleotide exchange factor for ADP-ribosylation factor; TRPC, transient receptor potential channel

ISSN: 1474-760X