Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution

Table 4 Number of loci containing nucleotides in register with the telomeric insertion*

	Number of observed loci (%)
No. of nucleotides in register with telomeric insertion	Mouse	Rat	Human	Chimpanzee	No. of expected loci (%)
0^†	11 (23)	16 (25)	1 (20)	1 (33)	(75)
1 or more^‡	36 (77)	47 (75)	4 (80)	2 (67)	(≤ 25)
2 or more^§	26 (55)	31 (49)	3 (60)	2 (67)	(≤ 6.25)
3 or more^¶	16 (34)	21 (33)	2 (40)	1 (33)	(≤ 1.56)
4 or more^¥	8 (17)	11 (17)	1 (20)	0 (0)	(≤ 0.39)

* For this analysis we utilized the informative species-specific loci listed in Additional data files 4 and 6, namely 47 mouse, 63 rat, 5 human and 3 chimpanzee ITS loci. ^†This class includes the loci in which the last nucleotide at the 3' end of the break is not in register with the inserted telomeric repeat insertion. ^‡This class includes all loci with in register nucleotides. This class, together with the previous class comprises the totality of the loci. ^§These loci are also included in the '1 or more' class. ^¶These loci are also included in the '1 or more and 2 or more' classes. ^¥These loci are also included in the '1 or more, 2 or more and 3 or more' classes.

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