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Figure 2 | Genome Biology

Figure 2

From: Contribution of telomerase RNA retrotranscription to DNA double-strand break repair during mammalian genome evolution

Figure 2

Microhomology between break sites and inserted telomeric repeats. Telomeric repeats are in red; in the empty ancestral loci the nucleotides in register with the inserted telomeric repeats are boxed. (a) Mouse specific ITS at the MMU12qA1 locus; an AGGG tetranucleotide from the orthologous rat empty locus RNO6q15 is in register with the inserted telomeric repeats. (b) Rat specific ITS at RNO14q21; a GGG trinucleotide from the orthologous mouse locus MMU3qB3 is in register with the inserted telomeric repeats. (c) The human specific ITS at HSA11q24 was inserted together with seven random nucleotides; a TA dinucleotide from the orthologous chimpanzee PTR9 locus is in register with the inserted telomeric repeats.(d) The insertion of the chimpanzee specific ITS at PTR22 occurred together with a 7 bp deletion; an AGG trinucleotide from the orthologous human locus HSA21q22 is in register with the inserted telomeric repeats.

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Genome Biology

ISSN: 1474-760X

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