Figure 1

Overview of guilt-by-association phenotype prediction. Guilt-by-association phenotype prediction employs a functional gene network, represented here as circles (genes) connected by lines (functional linkages), and a seed set of genes (blue filled circles) whose disruption is known to give rise to the phenotype of interest. Neighboring genes in a functional gene network (red filled circles) are candidates for also giving rise to the phenotype. Candidates are prioritized by the sum of their network linkage weights to the set of seed genes. A gene strongly linked to multiple seed genes will thus rank more highly than a gene weakly linked to a single seed gene. Networks in Figures 1, 5, and 7 were drawn with Cytoscape [73].