A new computational approach to analyze human protein complexes and predict novel protein interactions

Table 3 Percentage of synchronously peaking genes in the Thy-Noc dataset

	Peaks of expression (% of peaking genes per complex)
Protein complex	2 h-0 h	4 h-2 h	6 h-4 h	8 h-6 h	10 h-8 h	12 h-10 h	14 h-12 h
AP2	50	25	25	0	25	25	50
ARC	80	0	0	80	0	60	0
Arp2-3	0	60	40	0	20	0	40
ATP_F0	0	10	10	20	10	0	80
ATP_F1	0	33	0	33	0	0	33
APC	50	25	25	38	13	13	63
COX	0	25	38	0	25	0	50
Centrosome	27	22	14	20	24	31	39
Dynactin	14	0	14	14	14	14	71
Exocyst	29	43	29	57	14	43	43
Exosome	20	20	40	0	0	0	60
FA	34	28	34	30	9	30	40
GTC	33	17	33	17	33	33	33
LRS	6	22	6	6	6	0	72
MLRS	22	27	24	22	27	11	62
MSRS	20	37	33	20	7	10	63
Nucleopore	37	33	37	13	3	27	60
Nucleosome	13	54	13	25	8	8	38
ORC	50	17	17	50	17	33	0
PD	29	14	57	29	14	29	29
Proteasome	30	9	30	9	13	0	87
RFC	50	0	50	50	50	25	0
RNA Pol II	30	30	70	0	0	0	40
RNA Pol III	20	0	40	40	0	60	20
SNARE	14	57	29	14	29	29	14
SWI-SNF	33	17	33	8	0	17	42
SRP	75	25	25	0	0	25	75
SCF	33	33	33	0	33	0	100
SRS	10	40	35	10	15	5	60
TAFIID	23	38	8	23	23	0	46
TRAPP	33	17	0	17	17	0	50
VHL	0	0	50	0	0	0	50

For each protein complex the percentage of its synchronously peaking genes in each time interval is reported. AP2, adaptor-related protein complex 2; APC, anaphase promoting complex; ARC, axin related complex; ATP_F0, ATP synthase, H+ transporting, mitochondrial F0 complex; ATP_F1, ATP synthase, H+ transporting, mitochondrial F1 complex; COX, cytochrome c oxidase; FA, focal adhesion; GTC, golgi transport complex; MSRS, mitochondrial small ribosomal subunit; ORC, origin recognition complex; PD, pyruvate dehydrogenase; RNA Pol II, RNA polymerase II; SRP, signal recognition particle; TRAPP, trafficking protein particle complex; VHL, von Hippel-Lindau complex.

ISSN: 1474-760X