Table 1 Co-receptors and signal transducers in the Nogo-A-NogoR interaction
From: The reticulons: a family of proteins with diverse functions
Molecular region/interactor | Function/interaction | Reference(s) |
|---|---|---|
NogoA-24 | Increases binding affinity of Nogo-A to Nogo receptor (NogoR); binds NogoR directly | [15] |
Δ20 | Mediates fibroblast and growth cone collapse independently of NogoR | [16] |
p75NTR | Neurotrophin receptor; binds NogoR and mediates inhibition of neurite outgrowth via myelin-associated inhibitors | [72,73] |
LINGO-1 | Binds NogoR; activates Rho in complex with p75 and NogoR; mediates Nogo66-induced neurite outgrowth inhibition | [74,75] |
TAJ/TROY | Binds NogoR, activates Rho in complex with LINGO-1 and NogoR; absence attenuates myelin inhibition of neurite outgrowth | [76,77] |
EGFR | Kinase activity required for neurite outgrowth but EGFR does not bind NogoR | [78] |