Integrative analysis for finding genes and networks involved in diabetes and other complex diseases

Table 1 Marginal markers.

Total data set
	χ² (2 d.f.)	P value	Position on chromosome in cM	Confirmed from genome scan (LOD - 1 interval) or other references
TNFA	142.0	1.5 × 10^-32	47	6p21 (46-48 cM) [25]
D6S273	77.0	7.0 × 10^-18	45
D6S291	58.2	2.2 × 10^-13	49.5
D6S276	34.8	3.4 × 10^-8	44.4
D6S260	27.1	8.2 × 10^-7	29.9
D6S286	21.4	1.6 × 10^-5	89.8
D6S283	18.3	0.0001	109.2	[26]
D6S470	15.2	0.0005	18.2
D6S300	10.6	0.005	103.5	[26]
D17S798	9.8	0.007	53.4
D2S152	8.7	0.013	188.1	2q31-33 (177-204 cM) [25]
D2S125	7.0	0.03	260.6
D9S175	6.3	0.043	70.3
D8S261	6.1	0.048	37.0
D4S403	6.1	0.048	25.9
Selected markers
UK/US subset
D2S389	13.1	0.001	190	2q31-33 (177-204 cM) [25]
D16S769	9.4	0.009	50.6	16p12-q11.1 (26-71 cM) [25]
Th1	9.0	0.011	5.9	11p15.5 (0-14 cM) [25]
D16S289	8.1	0.017	105	16q22-q24 (100-121 cM) [25]
D10S183	6.7	0.035	60.6	10p14-q11 (52-66 cM) [25]
SCAND subset
D21S270	6.4	0.039	38.1	[27]

Markers of predictive value for T1D identified by decision tree analysis on T1D genome scan data from 1321 affected sib pair families. Markers identified in the total data set are ranked according to significance level (P < 0.05). Markers from data subsets are 'selected markers' and were selected on basis of whether they confirm loci from the latest T1D genome scan [25] or other references [26; 27]. D.f. = degrees of freedom.

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