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Table 2 Functional tests of candidate genes

From: Phenotypic and transcriptional response to selection for alcohol sensitivity in Drosophila melanogaster

Line Gene name MET (SE) p value Human orthologue Biological function
Canton S B Control 5.4 (0.01) NA NA NA
BG02818
BG02327
pipsqueak (psq) 3.5 (0.08)
5.75 (0.22)
<0.0001
0.1776
NA Regulation of transcription, DNA-dependent
BG02845 Toll (Tl) 3.6 (0.09) <0.0001 toll-like receptor 4* Defense response, immune response, Toll signaling pathway
BG02317
BG01705
BG02624
CG9650 3.6 (0.10)
4.9 (0.18)
5.6 (0.16)
<0.0001
0.1118
0.6381
B-cell lymphoma/leukemia 11A* Regulation of transcription from RNA polymerase II promoter, nucleic acid binding
BG02522 CG32560 3.8 (0.15) <0.0032 DAB2 interacting protein* Ras protein signal transduction, G-protein coupled receptor, MAPKKK cascade
BG01371 CG12505 4.3 (0.13) 0.0012 NA Nucleic acid binding
BG02560 CG9674 4.3 (0.14) 0.0042 NA Carbohydrate metabolism, amino acid biosynthesis
BG02210
BG02523
lamina ancestor (lama) 4.6 (0.10)
5.7 (0.36)
0.0014
0.6441
NP_775813, novel gene Unknown
BG01037 β ν integrin (βInt-ν) 4.6 (0.13) 0.0014 NA Signal transduction, defense response
BG02812
BG02830
Lipid storage droplet-2 (Lsd-2) 4.7 (0.12)
5.52 (0.23)
0.0083
0.7909
Adipose differentiation-related protein Lipid transport, sequestering of lipid
BG02518 CG8920 4.7 (0.11) 0.0025 Tudor domain containing protein 7 Nucleic acid binding
BG00987 smell impaired 35A (smi35A) 5.4 (0.14) 0.9859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 Olfactory behavior, response to chemical stimulus, nervous system development
BG01008 CG11133 5.6 (0.09) 0.6816 NA Unknown
BG02207
BG2034
lilliputian (lilli) 5.8 (0.11)
6.0 (0.28)
0.0905
0.1549
Fragile X mental retardation 2 protein* Regulation of transcription, DNA-dependent
BG02114
BG01509
CG30015 6.2 (0.17)
5.6 (0.31)
0.0120
0.4924
NA Unknown
BG02055 little imaginal discs (lid) 6.4 (0.11) 0.0283 Jumonji, AT rich interactive domain 1A Regulation of transcription, DNA dependent
BG01081 Glutamate oxaloacetate transaminase 1 (Got1) 6.5 (0.10) 0.0048 Glutamic-oxaloacetic transaminase 1 Amino acid metabolism, biosynthesis
BG01013 Poly(ADP-ribose) glycohydrolase (Parg) 6.5 (0.28) 0.0137 Poly(ADP-ribose) glycohydrolase* Carbohydrate metabolism, glycolysis
BG01389 Laminin A (LanA) 6.8 (0.15) 0.0020 laminin, alpha-5 Proteolysis, signal transduction, central nervous system development
BG02420 CG5946 6.9 (0.15) <0.0001 Cytochrome b5 reductase 3* Fatty acid desaturation, cholesterol metabolism
BG01144 CG17646 7.0 (0.16) 0.0002 NA Lipid metabolism, nucleotide binding
BG02731
BG02501
longitudinals lacking (lola) 7.1 (0.11)
5.8 (0.31)
<0.0001
0.5457
Zinc finger and BTB domain containing protein 3 Regulation of transcription from RNA polymerase II promoter, nervous system development
BG02276 CG7832 7.6 (0.13) <0.0001 NA Protein binding
BG02365 Malic enzyme (Men) 7.7 (0.24) <0.0001 Malic enzyme 1, NADP(+)-dependent Malate metabolism, carbohydrate metabolism
BG02180 nuclear fallout (nuf) 8.1 (0.18) <0.0001 RAB11 family interacting protein 4 Protein binding, actin cytoskeleton reorganization
BG01342 Kinesin-73 (Khc-73) 8.1 (0.21) <0.0001 kinesin family member 13A Protein targeting, exocytosis
BG02405
BG00525
corto 8.2 (0.21)
5.2 (0.21)
0.0086
0.2390
NA Cell cycle, RNA polymerase II transcription factor activity, protein binding
BG02128 lethal (1) G0007 (l(1)G0007) 8.3 (0.13) <0.0001 DEAH-box protein 38 Nuclear mRNA splicing, via spliceosome; nucleic acid binding
BG01672 CG14591 8.7 (0.20) <0.0001 Transmembrane protein 164 Unknown
BG01989 visgun (vsg) 8.8 (0.19) <0.0001 Transmembrane protein 123* Learning and/or memory, olfactory learning
BG00291 retinal degeneration B (rdgB) 8.9 (0.19) <0.0001 phosphatidylinositol transfer protein, membrane-associated 2 Lipid metabolism, sensory perception of smell, calcium ion transport
BG01536 Beadex (Bx) 8.9 (0.19) <0.0001 LIM-only protein 1* Nervous system development, regulation of transcription from RNA polymerase II promoter
BG01733 CG6175 9.0 (0.20) <0.0001 NA Unknown
BG01214 sugarless (sgl) 9.2 (0.20) <0.0001 UDP-glucose dehydrogenase Lipid metabolism, cell surface receptor linked signal transduction
BG02679
BG00990
wing blister (wb) 9.2 (0.15)
7.2 (0.13)
<0.0001
0.0093
laminin, alpha 2* Signal transduction
BG01127 muscleblind (mbl) 9.6 (0.17) <0.0001 muscleblind-like 1, isoform b* Peripheral nervous system development, response to stimulus, nucleic acid binding
  1. Lines that survived Bonferroni significance threshold = 0.0011 are indicated in bold font. Human orthologues have homology scores of >0.98 and bootstrap scores of >83% [86]. *Human orthologues associated with known diseases. NA, not applicable.