Figure 1

Experimental approach used to detect sex-specific splicing. Probes designed based on sequence clustering may target either constitutive or alternatively transcribed exons. Each panel shows a different example of probe distribution among constitutive and alternatively transcribed regions. For instance, '2+1+1' indicates that the corresponding gene has two probes targeting a common region and one probe targeting each of two alternatively transcribed regions, '3+1' indicates that the gene has three common probes and one probe that targets an alternatively transcribed region, and so on. For each probe, the figure shows its designating number, location in the transcript, and the ratio of the normalized and log-transformed (natural log) values between females (numerator) and males (denominator). Note that different probes that target the same subset of transcripts have similar values for the normalized log transformed male/female expression ratios, even if they are located in different exons. In contrast, probes that target alternatively spliced regions have different values for the normalized log transformed male/female expression ratios.