Figure 2

Positions of edited adenosines in human pri-miRNAs and antisense pri-miRNAs. Folded pri-miRNA structures were taken from the miRNA registry [6]. Antisense pre-miRNA structures were generated from the reverse complement pri-miRNA sequence using MFOLD [38]. Mature miRNA sequences of around 22 nucleotides and antisense mature miRNA sequences of around 22 nucleotides are indicated by red letters. Edited adenosines are highlighted in yellow. In antisense Hsa-mir-371, edited adenosines were found to reside in base-paired sequence extending beyond the annotated hairpin. Additional bases are in gray.