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Table 4 DDI-PPI mapping based on both single domain PPIs and the structural DDIs

From: Evolutionary conservation of domain-domain interactions

Organisma

E. coli

yeast

worm

fly

human

Number of PPIs

6,934

24,699

5,315

24,703

28,800

Number of PPIs with known domains (N)

6,038

18,202

3,351

14,939

25,004

Number of PPIs to which DDIs could be mapped (n) (%; n/N*100)

1,234 (20%)

5,048 (28%)

860 (26%)

3,983 (27%)

7,991 (32%)

  1. a Organism labeling: yeast: S. cerevisiae, worm: C. elegans, fly: D. melanogaster. DDI, domain-domain interaction; PPI, protein-protein interaction.