Evolutionary conservation of domain-domain interactions

Table 3 Common and unique DDIs by pair-wise organism comparison

	E. coli ^a	Yeast	Worm	Fly	Human	Total
E. coli	469 ^b (62%) ^c	211 (28%)	79 (10%)	64 (8%)	178 (23%)	759
yeast	211 (36%)	106 (18%)	163 (28%)	164 (28%)	352 (61%)	579
worm	79 (31%)	163 (65%)	24 (10%)	118 (47%)	193 (77%)	251
fly	64 (24%)	164 (60%)	118 (43%)	8 (3%)	239 (88%)	272
human	178 (20%)	352 (39%)	193 (22%)	239 (27%)	365 (41%)	897

^aOrganism labeling: yeast, S. cerevisiae; worm: C. elegans; fly, D. melanogaster.
^bValues in bold represent the DDIs unique to this organism. ^cThe percentage is calculated out of the total number of the organism's DDIs (right most column). The percentages in each line do not add up to 100% because there are DDIs that are shared by more than two organisms and they are counted more than once. DDI, domain-domain interaction.

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