Genome-wide identification of functionally distinct subsets of cellular mRNAs associated with two nucleocytoplasmic-shuttling mammalian splicing factors

Table 2 Summary of DAVID Gene Ontology classification of target mRNA populations

Cellular function	Gene Ontology group	U2AF (%)	PTB (%)
Gene expression	Transcription, DNA-dependent	13.1	10.6
	Transcription from Pol II promoter	3.8	3.1
	Negative regulation of transcription from Pol II promoter	0.7	-
	DNA packaging	1.4	-
	Nuclear mRNA splicing, via spliceosome	1.2	-
	Translation	1.1	-
Cell cycle	Cell proliferation	6.5	5.6
	Cell cycle	4.9	4.1
	Regulation of cell cycle	3	2.3
	G₁/S transition of mitotic cell cycle	0.6	-
	Mitotic cell cycle	1.3	-
Apoptosis	Death	-	3
	Apoptosis	-	2.8
	Negative regulation of apoptosis	0.9
Ubiquitination	Ubiquitin cycle	4.9	4.5
	Protein ubiquitination	2.6	2.1
Signaling	Intracellular signaling cascade	6	6.8
	Small GTPase mediated signal transduction	1.9	2.6
Intracellular transport and vesicles	Establishment of localization	-	10.4
	Endosome organization and biogenesis	-	0.4
	Endosome transport	-	0.3
	Vesicle-mediated transport	-	2.1

In the U2AF and PTB columns, '-' indicates that enrichment was not significant relative to the proportion of array genes belonging to the Gene Ontology group (P > 0.001). PTB, polypyrimidine tract binding protein; U2AF, U2 small nuclear RNP auxiliary factor.

ISSN: 1474-760X