Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

Table 2 Overview of mutants with a fitness defect of at least 20% or altered flux distribution

Mutants	Fitness defect in YPD		Fitness defect in MM		Altered intracellular flux distribution*
Total number of mutants	3 of 38		12 (+1)^† of 38		11 of 38
Singleton genes	fum1	gly1	fum1	pda1	fum1	pda1
			gly1	rpe1	lsc1	rpe1
			oac1	zwf1	mae1	zwf1
					oac1
Duplicate genes	adh1		adh1	sdh1	adh1	cox5A
			ald6	sol3	ald6	mdh1
			cox5A	(gnd1)
			mdh1

ISSN: 1474-760X