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Table 1 Fitness of mutants with deletions in flexible central metabolic reactions

From: Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast

 

Physiological fitness*

Competitive fitness†

 

Physiological fitness

Competitive fitness

Mutants

MM

YPD

YPD

Mutants

MM

YPD

YPD

Reference strain

1

1

1

    

adh1/YOL086C

0.47

0.57

0.79

mdh2/YOL126C

0.89

0.98

1.01

adh3/YMR083W

0.92

0.87

0.98

mdh3/YDL078C

1.00

0.96

1.01

ald5/YER073W

1.02

0.94

1

mls1/YNL117W

1

0.98

1

ald6/YPL061W

0.34

0.87

0.9

oac1/YKL120W

0.71

0.94

1.01

cox5A/YNL052W

0.63

0.91

1

pck1/YKR097W

1

0.96

1

ctp1/YBR291C

0.91

1

0.97

pda1/YER178W

0.41

0.98

1

dal7/YIR031C

0.94

0.85

1

pgm1/YKL127W

0.82

0.94

1

fum1/YPL262W

0.52

0.62

0.93

pgm2/YMR105C

0.90

1

1

gnd1/YHR183W

0

0.87

1.01

rpe1/YJL121C

0.33

0.94

0.88

gnd2/YGR256W

0.83

0.98

1

sdh1/YKL148C

0.72

0.94

1

gcv2/YMR189W

0.92

0.94

1

ser33/YIL074C

0.92

0.94

1.01

gly1/YEL046C

0.79

0.74

0.87

sfc1/YJR095W

0.84

0.96

1.01

gpd1/YDL022W

1

0.98

0.84

sol1/YNR034W

0.91

1

1.02

icl1/YER065C

1

1

1

sol2/YCRX13W

0.99

0.98

1

idp1/YDL066W

0.92

0.94

1.03

sol3/ YHR163W

0.71

0.94

1

idp2/YLR174W

0.86

0.96

0.95

sol4/ YGR248W

0.95

0.91

1.01

lsc1/YOR142W

1.05

0.93

1

tal1/ YLR354C

0.89

0.94

1

mae1/YKL029C

1.01

0.96

1

YGR043C

0.92

0.87

1.02

mdh1/YKL085W

0.72

0.91

1

zwf1/YNL241C

0.38

0.96

ND

  1. *Physiological fitness is defined as the maximal specific growth rate of a mutant normalized to the reference strain CEN.PK 113-7D ho :: kanMX4. The average from triplicate experiments is shown. The standard deviation was generally below 0.05. †From Steinmetz et al. [20]. ND, not detected.