Figure 2

Details of the interaction between human CTLA-4 and B7.1. (a) Overview of the interaction. The structure of soluble CTLA-4 monomer (left) interacting with soluble B7.1 monomer (right) is shown as a ribbon diagram, with the molecular surface of the soluble B7.1 monomer overlaid in white. (b) Close-up view of the interaction. The MYPPPY sequence from CTLA-4 (in ball and stick representation) interacts with residues forming a shallow depression in the IgV domain of B7.1. Three out of the five hydrogen bonds formed across the β sheets of the interacting domains are depicted by dashed lines. Reproduced with permission from [15].