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Table 1 Genes upregulated with quiescence

From: Identifying genetic networks underlying myometrial transition to labor

Increased gestation pattern group

Gene symbol

Fold-change at 14 days

Prostaglandin and cortisol synthesis

  

Hydroxysteroid 11-beta dehydrogenase 1

Hsd11b1

10.6

Decidual/trophoblast prolactin-related protein

Dtprp

6.2

Hydroxysteroid 11-beta dehydrogenase 2

Hsd11b2

3.6

Cytochrome P450, 11a

Cyp11a1

2.3

Prostaglandin-endoperoxide synthase 1

Ptgs1

2.0

Phospholipase inhibition

  

Annexin A8

Anxa8

4.4

Annexin A3

Anxa3

3.1

Uteroglobin

Utg

2.7

Calpactin

S100a10

2.5

Annexin A1

Anxa1

2.4

Annexin A2

Anxa2

2.1

Proteolysis and peptidolysis

  

Kidney-derived aspartic protease-like protein

Kdap

8.2

CTLA-2-beta

Ctla2b

8.1

Cathepsin Z

Ctsz

3.1

Dipeptidase 1

Dpep1

3.1

Procollagen C-proteinase enhancer protein

Pcolce

2.6

Lipocalin 7

Lcn7

2.6

Serine-type endopeptidases

  

Granzyme G

Gzmg

71.4

Granzyme D

Gzmd

45.7

Granzyme F

Gzmf

40.2

Granzyme E

Gzme

19.8

Granzyme C

Gzmc

10.7

RIKEN cDNA 2210021K23 gene

2210021K23Rik

2.9

Cathepsin G

Ctsg

2.2

Protease, serine, 11 (Igf binding)

Prss11

2.2

Granzyme B

Gzmb

2.1

Protease inhibitors

  

Tissue factor pathway inhibitor 2

Tfpi2

4.2

Serine protease inhibitor 14

Serpinb9e

3.3

Plasma protease C1 inhibitor

Serping1

2.7

Extracellular matrix remodeling and cell growth

  

Regulation of cell growth

  

Insulin-like growth factor binding protein 2

Igfbp2

12.4

Interleukin 1 receptor, type II

Il1r2

5.0

Glucocorticoid-induced leucine zipper

Gilz

3.8

Tumor necrosis factor, alpha-induced protein 2

Tnfaip2

3.3

c-Fos induced growth factor

Figf

3.2

Related RAS viral (r-ras) oncogene homolog 2

Rras2

3.0

Cysteine rich protein 2

Crip2

2.9

MORF-related gene X

Morf4l2

2.6

Epithelial membrane protein 1

Emp1

2.5

Four and a half LIM domains 1

Fhl1

2.3

S100 calcium binding protein A6 (calcyclin)

S100a6

2.3

Insulin-like growth factor binding protein 6

Igfbp6

2.1

Transforming growth factor, beta 2

Tgfb2

2.0

Integrin-mediated signaling pathway

  

Secreted phosphoprotein 1

Spp1

17.3

Connective tissue growth factor

Ctgf

2.8

Caveolin, caveolae protein

Cav

2.5

Ras homolog gene family, member A2

Arha

2.4

Structural constituent of cytoskeleton

  

Gelsolin

Gsn

2.4

Tropomyosin 4

Tpm4

3.1

Tubulin, beta 2

Tubb2

2.2

Extracellular matrix structural constituent

  

Microfibrillar associated protein 5

Mfap5-pending

6.9

Elastin

Eln

3.1

Procollagen, type XI, alpha 1

Col11a1

3.0

Fibromodulin

Fmod

2.4

Fibrillin 1

Fbn1

2.3

Procollagen, type V, alpha 2

Col5a2

2.2

Laminin, gamma 1

Lamc1

2.2

Procollagen, type I, alpha 2

Col1a2

2.2

G-protein signaling

  

Guanylate cyclase activator 2b

Guca2b

15.2

Chemokine orphan receptor 1

Cmkor1

5.0

Adrenomedullin

Adm

2.0

Guanine nucleotide binding protein, gamma 11

Gng11

2.0

Transcriptional regulation

  

Secreted frizzled-related sequence protein 4

Sfrp4

4.2

Kruppel-like factor 4

Klf4

3.0

C/EBP delta

Cebpd

2.3

Inhibitor of DNA binding 1

Idb1

2.1

X-box binding protein 1

Xbp1

2.0

Kruppel-like factor 2

Klf2

2.0

  1. Only upregulated genes with a relative fold-change of 2 or more versus non-pregnant mice at 14.5 days gestation and linked to biological categories highlighted by the expression analysis are shown. Full gene lists can be obtained online (see Additional data file 6).
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Genome Biology

ISSN: 1474-760X

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