Figure 2

Correlation of multiple datasets. Two protein interaction networks derived from large-scale experiments conducted by (a) Matrix of 1,349 by 1,349 interacting proteins from Gavin and coworkers [10] and (b) Matrix of 1,550 by 1,550 interacting proteins from Ho and coworkers [11]. These interactions are compared with the protein interaction network of regulators of the cell cycle (RCC; in panels d and e). (c) A supperimposed matrix. The two large protein interaction networks are overlaid and interactions common to both networks are highlighted in yellow. Interactions that are found only in one of the networks are colored red (interactions found only in the data reported by Gavin and coworkers [10]) and green (interactions found only in the data reported by Ho and coworkers [11]). (d) An overlap of the two interaction networks is compared with the RCC network. Interactions of the RCC network that are found in both large-scale pull down studies are highlighted in yellow. (e) A union of the two protein interaction networks is correlated with the RCC network. Interactions of the RCC network that are found in at least one protein interaction network are highlighted in yellow. Red is used to color the RCC network interactions that are not found in either protein interaction network. Interactions present in one of the protein interaction networks but not found in the RCC network are rendered in green.