The expression signature of in vitro senescence resembles mouse but not human aging

Table 1 Included aging studies

Study	Chip type	Species	Tissue	Age
Welle et al. [26]	HG U133 A+B	Human	Skeletal muscle	Old (n = 16) 66-77 years
				Young (n = 15) 21-24 years
Lu et al. [27]	HG U95 Av2	Human	Frontal cortex of brain	Old (n = 11) 73-106 years
				Young (n = 10) 26-42 years
Rodwell et al. [28]	HG U133 A+B	Human	Kidney cortex and medulla	Old (n = 28) 72-92 years
				Young (n = 11) 27-45 years
Lee et al. [25]	MU 6500	Mouse	Cerebellum and neocortex of brain	Old (n = 2/3*) 30 months
				Young (n = 3) 5 months
Lee et al. [29]	MG U74 A	Mouse	Heart	Old (n = 5) 30 months
				Young (n = 5) 5 months
Blalock et al. [30]	RG U34 A	Rat	Hippocampus, brain	Old (n = 10) 24 months
				Young (n = 9) 4 months

All studies of aging that were used in the aging to aging, and the aging to senescence comparisons are listed. Platform, species, tissues and grouping details for each study are shown. The Lee et al. [25] data was analyzed as two separate datasets, as it contained data from two different tissues - cerebellum and neocortex, and data on the aging CNS of other species was available for comparison.

ISSN: 1474-760X