Molecular processes during fat cell development revealed by gene expression profiling and functional annotation

Table 3 Significance of occurrence of predicted SREBP-1 binding sites in the promoters of co-expressed genes identified by clustering

SREBP-1	Putative target genes	Genes in cluster	Against total PromoSer database		Against total of all clusters
			CS	FE	CS	FE
Cluster 1	4	10	0.5000	0.7051	0.5339	0.7644
Cluster 2	11	27	0.5448	0.6892	0.6475	0.7812
Cluster 3	5	16	0.7076	0.8575	0.7697	0.8987
Cluster 4	9	12	0.0290	0.0289	0.0494	0.0484
Cluster 5	16	45	0.7787	0.8570	0.8568	0.9171
Cluster 6	10	20	0.1553	0.1554	0.2278	0.2277
Cluster 7	5	10	0.5000	0.5677	0.5000	0.6423
Cluster 8	31	66	0.2837	0.2827	0.4719	0.4711
Cluster 9	12	42	0.9025	0.9454	0.9414	0.9708
Cluster 10	22	41	0.1635	0.1635	0.2881	0.2877
Cluster 11	8	15	0.3230	0.3204	0.4057	0.4041
Cluster 12	25	45	0.0398	0.0404	0.1014	0.1014
PromoSer	5,456	12,493

Probabilities for over-representation (<0.05) of genes having a predicted SREBP-1 site relative to all unique regulated genes of PromoSer and to the total of all clusters. Cluster 4 is the only one with significantly increased occurrence of predicted SREBP-1 binding sites. CS, one-sided χ² test; FE, one-sided Fisher's exact test; SREBP, sterol-regulatory element binding protein.

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