Table 7 The most statistically significantly regulated functional groups in the fetal astrocyte cell lines based on their p values from t tests
From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart
GO group | GO identifier | Number of probe sets | p value | Mean of GO group | Mean of non-group members |
|---|---|---|---|---|---|
Collagen | GO:0005581 | 15 | 7.76E-07 | 0.33 | -0.01 |
Endoplasmic reticulum | GO:0005783 | 307 | 8.91E-07 | 0.03 | -0.02 |
Fibrillar collagen | GO:0005583 | 14 | 5.01E-06 | 0.29 | -0.01 |
Intracellular non-membrane-bound organelle | GO:0043232 | 122 | 7.94E-06 | -0.06 | -0.01 |
G-protein coupled receptor activity | GO:0004930 | 141 | 1.26E-05 | -0.09 | -0.01 |
Gametogenesis | GO:0007276 | 66 | 2.45E-05 | -0.08 | -0.01 |
Integral to plasma membrane | GO:0005887 | 734 | 2.57E-05 | -0.04 | -0.01 |
Intramolecular oxidoreductase activity, interconverting keto- and enol-groups | GO:0016862 | 11 | 2.19E-04 | 0.04 | -0.01 |
Carbohydrate transport | GO:0008643 | 16 | 2.40E-04 | 0.1 | -0.01 |
DNA metabolism | GO:0006259 | 309 | 3.98E-04 | -0.04 | -0.01 |
Extracellular matrix (sensu Metazoa) | GO:0005578 | 120 | 6.76E-04 | 0.09 | -0.02 |
Muscle development | GO:0007517 | 82 | 6.76E-04 | 0.06 | -0.01 |
Defense response | GO:0006952 | 381 | 8.51E-04 | -0.04 | -0.01 |
Cell adhesion | GO:0007155 | 227 | 8.91E-04 | 0.04 | -0.01 |
MHC class II receptor activity | GO:0045012 | 12 | 9.12E-04 | -0.12 | -0.01 |