Table 6 Most statistically significantly regulated functional groups in the fetal cerebellum tissues based on their p values from t tests
From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart
GO group | GO identifier | Number of probe sets | p value | Mean of GO group | Mean of non-group members |
|---|---|---|---|---|---|
Integral to plasma membrane | GO:0005887 | 933 | 1.26E-11 | 0.03 | 0 |
RNA binding | GO:0003723 | 469 | 6.31E-11 | -0.02 | 0.01 |
Structural constituent of ribosome | GO:0003735 | 212 | 1.12E-08 | -0.03 | 0.01 |
G-protein coupled receptor activity | GO:0004930 | 212 | 1.29E-08 | 0.06 | 0 |
Transmission of nerve impulse | GO:0019226 | 170 | 3.31E-08 | 0.06 | 0 |
Nucleus | GO:0005634 | 2194 | 3.55E-08 | -0.01 | 0.01 |
Cell surface receptor linked signal transduction | GO:0007166 | 592 | 2.24E-07 | 0.03 | 0 |
Ribosome | GO:0005840 | 147 | 4.68E-07 | -0.03 | 0.01 |
Defense response | GO:0006952 | 430 | 1.07E-06 | 0.04 | 0 |
Nucleobase, nucleoside, nucleotide and nucleic acid metabolism | GO:0006139 | 1596 | 5.37E-06 | -0.01 | 0.01 |
Neurogenesis | GO:0007399 | 337 | 9.55E-06 | 0.04 | 0 |
Eukaryotic translation initiation factor 4 complex | GO:0008304 | 13 | 2.51E-05 | -0.05 | 0.01 |
RNA metabolism | GO:0016070 | 286 | 4.57E-05 | -0.02 | 0.01 |
GABA receptor activity | GO:0016917 | 15 | 6.46E-05 | 0.1 | 0.01 |
DNA binding | GO:0003677 | 1126 | 7.24E-05 | -0.01 | 0.01 |