From: Primary and secondary transcriptional effects in the developing human Down syndrome brain and heart
GO group | GO identifier | Number of probe sets | p value | Mean of GO group | Mean of non-group members |
---|---|---|---|---|---|
Mitochondrion | GO:0005739 | 417 | 1.41E-14 | 0.03 | 0 |
Monovalent inorganic cation transporter activity | GO:0015077 | 86 | 3.72E-09 | 0.05 | 0 |
Nucleobase, nucleoside, nucleotide and nucleic acid metabolism | GO:0006139 | 1495 | 2.00E-07 | -0.02 | 0 |
Nucleus | GO:0005634 | 2072 | 5.50E-07 | -0.01 | 0 |
Nucleic acid binding | GO:0003676 | 485 | 1.23E-06 | -0.02 | 0 |
Oxidoreductase activity | GO:0016491 | 299 | 3.31E-06 | 0.02 | 0 |
NADH dehydrogenase activity | GO:0003954 | 31 | 3.80E-06 | 0.06 | 0 |
DNA binding | GO:0003677 | 1071 | 1.35E-05 | -0.02 | 0 |
Cytochrome-c oxidase activity | GO:0004129 | 25 | 8.51E-05 | 0.05 | 0 |
RNA binding | GO:0003723 | 466 | 1.48E-04 | -0.02 | 0 |
Transcription factor activity | GO:0003700 | 558 | 2.40E-04 | -0.02 | 0 |
Amine metabolism | GO:0009308 | 147 | 3.47E-04 | 0.03 | 0 |
RNA metabolism | GO:0016070 | 273 | 7.76E-04 | -0.02 | 0 |
Heterotrimeric G-protein GTPase, alpha-subunit | GO:0000263 | 8 | 8.51E-04 | 0.04 | 0 |
Helicase activity | GO:0004386 | 27 | 1.15E-03 | -0.05 | 0 |