Table 3 Proteins that physically interact with AP-2 transcription factors

APC

Adenomatous polyposis coli tumor suppressor

Basic region

Inhibition of β-catenin/TCF/LEF-dependent transcription

[16]

CITED2

Coactivator

DD

Transcriptional activation

[69]

CITED4

Coactivator

n.d.

Transcriptional activation

[70]

CDP

CCAAT displacement protein

DBD, DD

Repression of the hamster histone H3.2 promoter

[71]

DEK

Oncoprotein, chromatin remodeling

n.d.

Transcriptional activation

[72]

E1A

Transforming protein of adenovirus

DBD, DD

Repression of AP-2 target genes

[73]

c-Myc

Oncoprotein

Carboxyl terminus

Impairment of Myc/Max DNA-binding and transactivation

[14]

PARP

PolyADP-ribose polymerase

Carboxyl terminus

Transcriptional activation

[74]

PAX-6

Transcription factor

n.d.

Stimulation of gelatinase B activation

[75]

PC4

Coactivator

Transcriptional activation

[24]

P300/CBP

Coactivator

Amino terminus

Transcriptional activation

[69]

p53

Tumor suppressor

n.d.

Augmentation of p53-dependent transcription

[76]

RAP74

Subunit of transcription factor TFIIF

Central region containing DBD

Unknown

[74]

Rb

Retinoblastoma tumor suppressor

Amino terminus^†

Repression of the hamster histone H3.2 promoter; transcriptional activation of the E-cadherin gene

[77,78]

SP1

Transcription factor

Basic region

Transcriptional activation of the ovine CYP11A1 gene

[79]

SV40T

Transforming protein of SV40 virus

n.d.

Blocks DNA binding of AP-2 protein

[12]

UBC9

E2-conjugating enzyme

DBD, DD

Sumoylation

[80]

WWOX

Tumor suppressor

Amino terminus PY motif

Cytoplasmic localization PPPY motif

[17]

YB-1

Transcription factor

n.d.

Stimulation of gelatinase A transcription

[81]

YY1

Transcription factor

DBD, DD

Stimulation of the hamster histone H3.2 promoter

[82]