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Table 2 20E-induced, EcR-dependent genes

From: The genomic response to 20-hydroxyecdysone at the onset of Drosophila metamorphosis

Gene

20E

20E primary

EcRi -4 h

EcRi 0 h

EcRi 4 h

Function

Eip74A*

11.0

12.6

-4.9

-4.5

-2.0

Transcription factor

Drosomycin-2

8.1

 

-4.5

-7.3

-14.5

Defense response

CG14664

4.7

 

-16.3

-22.9

 

n/o

GST-E3

3.7

3.2

 

-1.9

 

Glutathione transferase

Eip78C*

3.6

3.3

-6.2

-6.9

-1.9

Nuclear receptor

CG10444

3.4

 

-4.1

-7.1

-2.1

Na+-dependent multivitamin transporter

Punch

3.0

2.4

-3.1

-8.1

-2.2

GTP cyclohydrolase I

CG5171

3.0

2.7

-1.7

-1.5

-3.5

Trehalose-phosphatase

CG2444

3.0

 

-2.8

-2.4

2.3

n/o

Cyp18a1*

2.9

8.3

-2.3

 

-1.7

Cytochrome P450

CG5391

2.7

 

-5.2

 

3.1

n/o

MESR3

2.6

 

-1.5

-3.0

-1.6

Ras signaling

CG3714

2.6

2.3

 

-1.7

 

Nicotinate phosphoribosyltransferase

rdgBbeta

2.5

4.6

 

-2.2

-2.4

Phosphatidylinositol transporter

CG8501

2.4

  

-1.9

-1.8

n/o

l(3)00305

2.4

1.9

 

-1.6

 

Serine/threonine kinase

CG11737

2.4

 

-2.3

-2.0

 

n/o

Cabut

2.3

5.9

-1.9

  

Transcription factor

CG17834

2.3

1.6

 

-2.1

-4.4

n/o

Sox box protein 14

2.3

2.9

-1.5

-1.7

 

Transcription factor

JIL-1

2.2

   

-3.0

Protein serine/threonine kinase

CG18212

2.2

  

-2.1

-1.8

n/o

CG13252

2.2

2.0

-2.1

-2.4

-2.7

n/o

raspberry

2.2

1.7

-1.9

-2.2

-1.8

IMP dehydrogenase

supernumerary limbs

2.2

  

-3.1

-2.6

Ubiquitin-protein ligase

CG16995

2.1

1.5

  

-2.8

Defense response

lamina ancestor

2.1

2.9

-1.6

-3.1

-2.4

n/o

CG33090

2.1

  

-3.9

-1.5

n/o

CG7701

2.1

  

-1.6

 

n/o

rhea

2.1

  

-1.9

-2.2

Actin binding

Ptp52F

2.1

2.2

-2.4

-1.6

 

Protein tyrosine phosphatase

CG4822

2.1

1.4

 

-3.1

-2.2

ATPase activity

big brain

2.1

   

-2.4

Water channel

brain tumor

2.0

2.9

 

-1.7

 

Translation regulator

CG11529

2.0

 

-7.1

-2.2

2.0

Serine-type endopeptidase

CG11509

2.0

1.9

  

-1.6

n/o

CG3348

2.0

4.5

-3.0

-3.1

-1.7

n/o

CG9989

2.0

 

-1.5

-2.2

-2.5

n/o

blue cheese

1.9

2.0

 

-2.0

-1.6

Intracellular protein transport

CG14073

1.9

2.4

  

-1.5

Ankyrin-like

kruppel homolog 1*

1.9

3.5

 

-1.8

-2.2

Transcription factor

CRMP

1.8

2.6

 

-2.3

-3.2

Dihydropyrimidinase

CG9801

1.8

3.1

 

-4.5

-5.7

n/o

CG8483

1.8

5.4

-3.0

-2.8

 

Defense response

CG9005

1.8

2.4

-1.8

-1.8

-1.8

Cell adhesion

vrille

1.6

3.5

  

-1.6

Transcription factor

CG1342

1.6

2.4

 

-2.6

-8.5

Proteinase inhibitor I4, serpin

DHR3*

1.6

2.3

  

-2.9

Nuclear receptor

Eip75B*

1.5

2.8

-1.6

  

Nuclear receptor

hairy

 

4.4

 

-1.8

-1.6

Transcription factor

CG9192

 

3.3

  

-1.7

n/o

CG5249

 

3.0

  

-1.5

Transcription factor

black

 

2.7

-3.0

-7.0

 

Glutamate decarboxylase 2

CG2016

 

2.1

-2.0

-2.0

-2.0

n/o

CG12539

 

2.1

-1.7

 

-1.6

Glucose dehydrogenase

CG8788

 

2.0

-1.5

-2.5

-1.8

n/o

  1. Genes that show at least a twofold induction with either 20E alone (20E), or 20E + cycloheximide (20E primary) are listed in the order of their fold-induction by 20E alone. Downregulation of these genes upon EcR RNAi is shown for each time point, -4, 0, or 4 hours relative to puparium formation. Function is inferred from gene ontology on FlyBase. [40]. Asterisks denote previously identified 20E-regulated genes. n/o, no ontology.