Figure 5

Heatmap and in situ hybridization data for genes in the stop cluster. (a) The temporal expression profiles of genes of the cluster are represented by a heatmap. The highest levels of expression are indicated by the brightest shades of red, while lower expression levels are represented by progressively brighter shades of green, as indicated by the scale bar. Genes are ordered with the most highly expressed first, and gene names are shown to the right of the maps. (b-e) A temporal series of in situ studies revealing expression of one gene in this class, Notch, at 0.5 h (b), 3 h (c), 12 h (d) and 24 h (e), showing how mRNA levels in the leading-edge keratinocytes appear to dip during the period of re-epithelialization and then increase again coincident with the time at which epidermal fronts contact one another. Arrows highlight region of gene expression. Scale bar = 100 μm.