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Table 1 Character of residues in the conserved positions of the ligand-binding box

From: Identification of the prokaryotic ligand-gated ion channels and their implications for the mechanisms and origins of animal Cys-loop ion channels

Ratio of aromatic residues

Overall aromaticity

Position*

R104(D)

L112(D)

W143(C)

T144(C)

Y185(C)

Y192(C)

 

Bacteria

0.2

0.53

0.2

0.0

0.6

0.53

2.1

Animals

0.14

0.22

0.82

0.0

0.54

0.89

2.6

  1. *The positions correspond to the D and C chains of ACHB (PDB: 1UV6)
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Genome Biology

ISSN: 1474-760X

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