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Table 5 Comparison of known essential human nutrients with corresponding biosynthetic pathways in MetaCyc and in HumanCyc

From: Computational prediction of human metabolic pathways from the complete human genome

Essential nutrient in humans

Biosynthetic pathway in MetaCyc?

Biosynthetic pathway inferred in humans?

Amino acids

  

Arginine

Y

N

Histidine

Y

N

Isoleucine

Y

N

Leucine

Y

N

Lysine

Y

N

Methionine

Y

N

Phenylalanine

Y

N

Threonine

Y

N

Valine

Y

N

Vitamins

  

Ascorbic acid (Vitamin C)

Y

N

Biotin (Vitamin H)

Y

N

Folic acid (Vitamin M)

Y

N

Niacin (Vitamin B3)

N

N

Pantothenic acid

Y

Y

Pyridoxine (Vitamin B6)

N

N

Riboflavin (Vitamin B2)

Y

N

Thiamine (Vitamin B1)

Y

N

Cobalamin (Vitamin B12)

Y

N

Retinol (Vitamin A)

N

N

Vitamin D

N

N

Tocopherol (Vitamin E)

N

N

Vitamin K

N

N

  1. Note that a pathway cannot be predicted in HumanCyc if it does not exist in MetaCyc.
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Genome Biology

ISSN: 1474-760X

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