Table 1 Properties of human MAP2/Tau family genes
From: The MAP2/Tau family of microtubule-associated proteins
Gene | Locus | Predicted exons | Splice form | Number of microtubule-binding repeats | Alternatively spliced exons |
|---|---|---|---|---|---|
MAP2 | 2q34-q35 | 18 | Isoform 1 (MAP2b) | 3 | +9, +10, +11, -16 |
| Â | Â | Â | Isoform 2 (MAP2c) | 3 | -9, -10, -11, -16 |
| Â | Â | Â | Isoform 3 | 4 | +9, +10, +11, +16 |
| Â | Â | Â | Isoform 4 (MAP2d) | 4 | -9, -10, -11, +16 |
| Â | Â | Â | MAP2a | Unknown | +8, +9, +10, +11, (16?) |
Tau | 17q21.1 | 17 | Isoform 1 (HMW-tau) | 4 | +2, +3, +4A, +6, +10 |
| Â | Â | Â | Isoform 2 (tau 4R/2N) | 4 | +2, +3, -4A, -6, +10 |
| Â | Â | Â | Isoform 3 (tau 4R/0N) | 4 | -2, -3, -4A, -6, +10 |
| Â | Â | Â | Isoform 4 (tau 3R/0N) | 3 | -2, -3, -4A, -6, -10 |
MAP4 | 3p21 | 23 | Various isoforms | 3-5 | Various |