A first-draft human protein-interaction map

Table 1 The number and accuracy of human protein interactions predicted by different model organism protein-interaction datasets

Data source	Predicted human interactions	Interactions sharing GO terms
		Number	%
All	71,496	12,724	24.9
Yeast	55,231	10,727	26.2
Fly	12,059	1,404	19.0
Worm	4,494	753	24.4
All core	11,487	3,133	38.1
Core yeast	6,061	2,146	45.4
Core fly	2,889	488	27.8
Core worm	2,701	597	32.3
Two species	288	154	74.8
Two species (core)	160	95	88.0
Two methods	2,166	829	60.6
Random pairs	71,496	6,053	14.6

The table lists the total number of interactions predicted by each interaction dataset, and the number of these interactions that connect proteins that share at least one GO term (at level 3 or deeper in the GO hierarchy). The percentages are relative to the total number of non-self interactions where both proteins have at least one GO annotation. All, all predicted human protein interactions; Yeast/worm/fly, interactions predicted by the yeast, worm or fly interaction maps; All core, all interactions predicted by the high-confidence subsets of each model organism interaction map (see Materials and methods); Two species, interactions predicted by more than one model organism interaction map; Two species (core), interactions predicted by the high-confidence subset of interactions from more than one model organism; Two methods, interactions predicted by data derived from more than one different interaction assay; Random pairs, the data for a randomly generated interaction network.

ISSN: 1474-760X