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Figure 7 | Genome Biology

Figure 7

From: Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFadeletion hotspots

Figure 7

Paralog and ortholog sequence similarity under gene conversion, assuming different levels of sequence divergence between the paralogs before speciation. Sequence similarities represent averages over 1,000 simulations. The two pairwise paralog comparisons (p1 vs d1 and p2 vs d2) are averaged together, as are the two ortholog comparisons (p1 vs p2 and d1 vs d2). Length of simulation 8 × 106 years; generation time 20 years; base substitution rate 4 × 10-8 per nucleotide per generation; gene conversion rate 4 × 10-5 per locus per generation (equivalent to 1.4 × 10-6 per site per generation); mean gene conversion tract length 352 bp; gene conversion directionality 0.5 (unbiased).

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