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Figure 6 | Genome Biology

Figure 6

From: Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFadeletion hotspots

Figure 6

The effect of varying gene conversion rate on paralog and ortholog sequence similarity. Sequence similarities represent averages over 1,000 simulations. The two paralog pairwise comparisons (p1 vs d1 and p2 vs d2) are averaged together, as are the two ortholog comparisons (p1 vs p2 and d1 vs d2). Length of simulation 8 × 106 years; generation time 20 years; base substitution rate 4 × 10-8 per nucleotide per generation; gene conversion rate 0.1 (representing 4 × 10-5 per locus per generation - equivalent to 1.4 × 10-6 per site per generation); initial paralog sequence divergence 2%; gene conversion directionality 0.5 (that is, unbiased); mean gene conversion tract length 352 bp.

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